Development and evaluation of innovative treatment options for acute and chronic inflammatory diseases is urgently needed, due to the many adverse aspects of available drugs such as antibiotics and cortisone. In this context, sulfated polysaccharides (fucoidanes) from brown algae appear to be a promising anti-inflammatory approach.
As part of this research project, we will comprehensively analyze the impact of different fucoidans from different brown algae species on human monocytes and macrophages as central immune cells of inflammation regulation. On the one hand, the focus is on the extraction, characterization and optimization of different fucoidans in view of its chemical structure and purity and furthermore on the therapeutic potential with regard to the impact on cytokine secretion, adhesion and differentiation of human monocytes and macrophages.
The ultimate goal of our research is the feasibility of a future application of the identified and optimized fucoidans for topical treatment of inflammatory diseases of the upper respiratory tract.